01重点学术场次Priority Sessions1 场
本专题的重点场次包含 Hot Line、LBCS、New ESC Guidelines、Ask the Trialists、Guidelines in Practice、Great Debates 等。
炎症与免疫1 场
LBCS
晚期基础与转化科学
Late-Breaking Basic & Translational Science
新型心肌肌球蛋白激活剂 Danicamtiv 与右心室功能改善相关：DCM 患者的临床前与临床证据
Danicamtiv, a Novel Cardiac Myosin Activator, Is Associated with Improved Right Ventricular Function: pre-clinical and clinical evidence in patients with DCM
环境空气污染经 IL6R 炎症信号与 Y 染色体剂量依赖性丢失及不良心血管结局相关：从 20 万名男性到单个骨髓细胞
Ambient Air Pollution Associates with Dose-Dependent Loss of the Y Chromosome via IL6R Inflammatory Signalling and Adverse Cardiovascular Outcomes: From 200,000 Men to Single Bone Marrow Cells
动态 DPP3 检测用于急性心肌梗死相关心源性休克的床旁快速危险分层
Dynamic DPP3 profiling for rapid bedside risk stratification in acute myocardial infarction-related cardiogenic shock
破解慢性与急性冠脉综合征中的网状血小板：S100A8/9-TLR4 信号失调的转录组与蛋白质组证据
Deciphering Reticulated Platelets Across Chronic and Acute Coronary Syndromes: Transcriptomic and Proteomic Evidence for S100A8/9-TLR4 Signaling dysregulation
精细调节的 mTORC1 抑制保留肝脏与心脏炎症特征以挽救 HFpEF
Fine-tuned mTORC1 inhibition preserves inflammatory signature in liver and heart to rescue HFpEF
巨噬细胞 RNASET2 与 HFpEF 中固有 RNA 感知程序激活相关
Macrophage RNASET2 is associated with activation of innate RNA-sensing program in heart failure with preserved ejection fraction
03本领域中国研究China Abstracts90 篇
| 研究标题 | 第一作者 | 所在机构 |
|---|---|---|
| 动脉粥样硬化与脑血管病 · 11 篇 | ||
代谢紊乱在动脉粥样硬化与腹主动脉瘤中的不同致病作用——ACADM介导脂肪酸β氧化通路的关键角色 Distinct pathogenic roles of metabolic disturbances in atherosclerosis versus abdominal aortic aneurysm – Critical role of ACADM-mediated fatty acid β-oxidation pathway | Jun Pu | 上海交通大学医学院附属仁济医院 |
血管平滑肌细胞中组蛋白乳酸化介导的代谢重塑经促进乳酸积累加重主动脉瘤与夹层 Histone lactylation-mediated metabolic remodeling in vascular smooth muscle cells aggravates aortic aneurysm and dissection via promoting lactate accumulation | Li Wei Liu | 复旦大学附属中山医院 |
NRP1与AP2M1互作经驱动PDGFRβ内吞促进血管钙化 NRP1 interaction with AP2M1 promotes vascular calcification by driving endocytosis of PDGFRβ | Huiqi Chen | 中山大学附属第八医院 |
TNF-α经HuR依赖的R-loop稳定促进主动脉夹层中WNT5B转录 TNF-α promotes WNT5B transcription via HuR-dependent R-loop stabilization in aortic dissection | Yan Xia | 中山医院 |
慢性交感激活经调控血管周脂肪β3AR/p-CREB/SFRP5减轻动脉粥样硬化炎症 Chronic sympathetic activation decreases atherosclerotic inflammation by regulating β3AR/p-CREB/SFRP5 in perivascular adipose tissue | Yue Yu | 复旦大学 |
过表达白细胞介素10的巨噬细胞通过靶向乳酸-CEBPB轴抑制致病性血管平滑肌细胞表型转化缓解动脉粥样硬化 Macrophages overexpressing interleukin-10 alleviate atherosclerosis by targeting the lactate-CEBPB axis to inhibit pathogenic VSMC phenotypic transitions | Mingyi Wang | 解放军总医院第六医学中心 |
血管周脂肪细胞Serpina3c缺失损害MAM依赖的线粒体钙稳态并加速动脉粥样硬化 Serpina3c deficiency in perivascular adipocytes impairs MAM-dependent mitochondrial calcium homeostasis and accelerates atherosclerosis | Guang Hong Zhou | 东南大学附属中大医院 |
过表达CCR2的水凝胶化巨噬细胞促进动脉粥样硬化治疗中的靶向脂质清除与免疫调节 CCR2-Overexpressing hydrogelated macrophages facilitate targeted lipid clearance and immunomodulation in atherosclerosis treatment | Chenghui Yan | 北部战区总医院 |
IFIT3定义新型血管平滑肌细胞亚群加重血管重构疾病进展 IFIT3 defines a novel subset of vascular smooth muscle cells to exacerbate the development of vascular remodeling disease | Wenhui Lin | 复旦大学附属中山医院 |
琥珀酸诱导组蛋白琥珀酰化经激活FRA1/CREB3L2轴加速动脉钙化 Succinate induces histone succinylation to accelerate arterial calcification by activating FRA1/CREB3L2 axis | Zhengyan Guan | 中山大学附属第八医院 |
外泌体介导的体内FAP靶向CAR-T细胞治疗动脉粥样硬化 Exosome mediated in vivo FAP targeting CAR-T cell therapy in atherosclerosis | Ming Yi | 首都医科大学宣武医院 |
| 白细胞、炎症与免疫 · 10 篇 | ||
细胞深度蛋白质组学解析GLP-1受体激动剂的NLRP3炎症小体与免疫血栓效应：对照干预研究 Cellular deep proteomic profiling elucidates NLRP3 inflammasome and immunothrombosis effects of GLP-1 receptor agonist: a controlled intervention study | Yap-Hang Will Chan | 香港大学 |
体内单细胞CRISPR筛选揭示Slc7a8是心肌梗死后修复的关键分子 In vivo single-cell CRISPR screening reveals that Slc7a8 is a key molecule in post-myocardial infarction repair | Sirui Huang | 复旦大学附属中山医院 |
动脉三级淋巴器官编码致病性高亲和力自身抗体驱动动脉粥样硬化 Artery Tertiary Lymphoid Organs (ATLOs) encode a pathogenic high affinity autoantibody driving atherosclerosis | Changjun Yin | 中山大学附属第一医院 |
运动训练通过调控B细胞浸润与功能预防心肌梗死 Exercise training protects against myocardial infarction by regulating B cell infiltration and function | Shuqin Liu | 上海大学 |
ILC2来源IL-9激活调节性T细胞促进心肌梗死后修复 ILC2-derived IL-9 activates regulatory T cells to facilitate post-myocardial infarction repair | Yuxiao Feng | 上海市胸科医院 |
人iPSC衍生心肌细胞作为猴痘病毒诱发心肌炎的体外模型与抗病毒筛选平台 Human iPSC‑derived cardiomyocytes as an in vitro model for monkeypox virus–induced myocarditis and antiviral screening | Chun Ka Wong | 香港大学 |
内毒素耐受通过巨噬细胞表观遗传与代谢重编程调节移植心脏免疫微环境 Endotoxin-tolerance modulates the immune microenvironment of transplanted hearts through macrophage epigenetic and metabolic reprogramming | Ting Wang | 浙江大学医学院附属第一医院 |
LUBAC介导的线性泛素化驱动心脏缺血-再灌注损伤中巨噬细胞促炎激活 LUBAC-mediated linear ubiquitination drives proinflammatory activation of macrophage in cardiac ischemia-reperfusion injury | Yunfan Yang | 复旦大学附属中山医院 |
新生儿S100A8⁺巨噬细胞亚群统筹心肌梗死后炎症消退与心脏再生 A neonatal S100A8⁺ macrophage subset orchestrates inflammation resolution and cardiac regeneration after myocardial infarction | Heng Yeh Lu | 台湾大学医学院 |
心肌细胞内在的RXRγ–SOCS3轴调控巨噬细胞驱动的病毒性心肌炎炎症 A cardiomyocyte-intrinsic RXRγ–SOCS3 axis governs macrophage-driven inflammation in viral myocarditis | Zhou Zhou | 华中科技大学同济医学院 |
| 缺血、梗死与心肌保护 · 9 篇 | ||
IGFBP2作为辅酶A传感器调控心脏缺血-再灌注损伤中的心肌细胞铁死亡 IGFBP2 serves as a coenzyme A sensor to regulate cardiomyocyte ferroptosis in cardiac ischemia-reperfusion injury | Rongrong Wu | 浙江大学医学院附属第二医院 |
心外膜脂肪棕色化通过抑制M1巨噬细胞来源小细胞外囊泡中ACSL1货物装载减轻缺血/再灌注损伤心肌细胞铁死亡 Epicardial adipose tissue browning attenuates cardiomyocyte ferroptosis in ischemia/reperfusion injury by suppressing ACSL1 cargo loading in M1 macrophage-derived small extracellular vesicles | Yifei Wang | 东南大学附属中大医院 |
BDNF经YY1诱导DECR1上调对心肌梗死发挥心脏保护作用 BDNF exerts cardioprotection against myocardial infarction via YY1-induced DECR1 upregulation | Juying Qian | 中山医院 |
HIF-1α/PLA2g2a/LPC通路在心肌缺血-再灌注损伤后心外膜脂肪心脏纤维化中的机制 Mechanism of theHIF-1α/PLA2g2a/LPC pathway in epicardial adipose tissue in cardiac fibrosis following myocardial ischemia-reperfusion injury | Hao Zhang | 首都医科大学附属北京友谊医院 |
巨噬细胞Mincle通过识别冠状动脉内皮RTN4驱动心肌缺血-再灌注损伤 Macrophage Mincle drives myocardial ischemia-reperfusion injury by recognizing coronary endothelial RTN4 | Shiju Ye | 浙江大学医学院附属邵逸夫医院 |
蒙奇梅氏酵母来源雌三醇经CD14-TLR4轴驱动巨噬细胞炎症加重心肌缺血-再灌注损伤 Meyerozyma guilliermondii-derived estriol drives macrophage inflammation via the CD14-TLR4 axis to exacerbate myocardial ischemia-reperfusion injury | Jie Liu | 同济大学附属上海市第十人民医院 |
丁酸钠通过调控巨噬细胞极化改善心肌缺血-再灌注损伤后心脏免疫微环境 Sodium butyrate improves the cardiac immune microenvironment after myocardial ischemia-reperfusion injury by regulating macrophage polarization | Jing Gao | 天津市胸科医院 |
MsrB1介导心肌缺血再灌注损伤中巨噬细胞-内皮修复性通讯的机制 The mechanism of MsrB1 mediating the macrophage-endothelial reparative communication in myocardial ischemia reperfusion injury | Muyin Liu | 复旦大学附属中山医院 |
乳酸菌通过调控丁酸生成改善心肌缺血-再灌注损伤 Lactobacillus ameliorates myocardial ischemia-reperfusion injury by regulating butyrate production | Jing Gao | 天津市胸科医院 |
| 干细胞、细胞周期与细胞衰老 · 7 篇 | ||
维奈克拉经衰老细胞清除活性与SOX9/LH3介导的细胞外基质重塑减轻血管钙化 Venetoclax attenuates vascular calcification through combined senolytic activity and SOX9/LH3-mediated ECM remodeling | Qiwei He | 中山大学附属第八医院 |
孕酮经孕酮受体亚型b依赖性抑制KLHL38与稳定SIRT1缓解血管内皮衰老 Progesterone alleviates vascular endothelial senescence through progesterone receptor isoform b–dependent repression of kelch-like family member 38 and stabilisation of sirtuin 1 | Dingyi Lyu | 重庆医科大学附属第一医院 |
前列腺素E2-EP2信号经QSOX1上调诱导线粒体功能障碍与促炎表型转换驱动血管老化 Prostaglandin E2-EP2 signalling drives vascular aging by inducing mitochondrial dysfunction and pro-inflammatory phenotypic switching via QSOX1 up-regulation | James Jiqi Wang | 同济医院-同济医学院 |
Let-7b-5p通过抑制炎性血管平滑肌细胞PANoptosis预防主动脉夹层 Let-7b-5p protects against aortic dissection by inhibiting inflammatory vascular smooth muscle cell PANoptosis | Hsin-Ying Lu | 台北医科大学 |
过度脂肪酸氧化驱动脂毒性血管老化：桦木酸靶向PPAR-α/CPT1A轴的治疗策略 Excessive fatty acid oxidation drives lipotoxic vascular aging: therapeutic targeting of the PPAR-α/CPT1A Axis by betulinic acid | Feng Cao | 中国人民解放军总医院 |
乳酸诱导的液-液相分离调控可变剪接促进心脏再生 Lactate-induced liquid-liquid phase separation modulates alternative splicing to promote cardiac regeneration | Mingchuan Liu | 唐都医院 |
E3泛素连接酶靶向核仁素并调控其相分离以抑制心肌梗死心脏核糖体生物合成 E3 ubiquitin ligase targets nucleolin and modulates its phase separation to suppress ribosome biogenesis in myocardial infarction hearts | Yangxin Li | 苏州大学附属第一医院 |
| 纤维化 · 6 篇 | ||
Bmp6-Bmpr2信号介导内皮-基质成纤维细胞的时空互作调控心肌梗死后心脏纤维化 Bmp6-Bmpr2 signalling mediates endothelial-matrifibrocyte time-spatial interaction to regulate cardiac fibrosis after myocardial infarction | Cheng Ni | 浙江大学医学院附属第二医院 |
肿瘤抑制素M将心脏成纤维细胞重编程为免疫调节状态 Oncostatin M reprogrammes cardiac fibroblasts toward an immunoregulatory state | Ruopu Li | 阜外医院 |
细胞外基质来源的运动因子COL1A2-pep1经mtDNA-cGAS-STING通路增强线粒体自噬减轻心脏重构 ECM-derived exerkines COL1A2-pep1 attenuate cardiac remodeling by enhancing mitophagy through the mtDNA-cGAS-STING pathway | Ling-Hong Shen | 上海市胸科医院 |
04企业卫星会Industry Symposia6 个系列
赞助商分布2 场 · Abbott 1 场 · SOBI 1 场 · Cleveland Clinic 1 场 · Sanofi 1 场 · Novartis
指南与标准1 个系列
Abbott
心衰指南如何重构药物治疗与器械治疗的关系
How the heart failure guidelines redefine the relationship between the guideline-directed medical therapy and device therapies
欢迎、专家展示与会议目标
Welcome, panel presentation, session objectives
解读心力衰竭指南
Navigating the heart failure guidelines
专家讨论
Panel discussion
肺动脉压力监测将指南转化为心力衰竭临床实践
Pulmonary artery pressure monitoring translating guidelines into heart failure practice
专家讨论
Panel discussion
心衰指南：对经导管缘对缘修复疗法的影响
Heart failure guidelines: impact on the transcatheter edge-to-edge repair therapies
… 另 6 项讲题
综合与其他5 个系列
SOBI
载脂蛋白 C-III 抑制：重度高甘油三酯血症风险管理进入新时代
ApoC‑III inhibition: entering a new era in managing risks of severe hypertriglyceridemia (sHTG)
欢迎与议程
Welcome and agenda
甘油三酯：心脏病学家的关注——风险是什么？
Triglycerides: a cardiologists’ concern – what are the risks?
靶向 ApoC-III：甘油三酯管理的新时代
ApoC-III targeting: a new era in triglyceride management
我如何管理重度高甘油三酯血症患者
How I manage my patients with sHTG
问答、专家讨论与闭幕致辞
Q&A, panel discussion and closing remarks
Cleveland Clinic
厚心脏之病：病例讨论
Disease of the thick heart: case-based discussion
精准诊断与治疗的新世界
Brave new world of precision diagnosis and therapies
表型趋同还是因果级联：狭窄、紊乱与浸润
Phenotypic convergence or causal cascade: stenosis, disarray, and infiltration
用 GLP-1 受体激动剂改善 HFpEF 结局
Improving outcomes in HFpEF with GLP-1 receptor agonist
酶之谜
The enzyme enigma
厚壁心脏疾病——小组讨论
Disease of the thick heart - panel discussion
Sanofi
回望以向前：通过早期优化 LDL-C 管理改变 ASCVD 轨迹
Looking back to move forward: changing the trajectory of atherosclerotic cardiovascular disease through early optimisation of low-density lipoprotein cholesterol care
从失败中学习：我们如何改变动脉粥样硬化性心血管疾病的轨迹？
Learning from failure: how do we change the trajectory of atherosclerotic cardiovascular disease?
关上二次事件之门：复发性心血管事件为何仍在发生？
Closing the door on the second event: why are recurrent cardiovascular events still happening?
在风险袭来之前抓住它：我们能有效预防首次心肌梗死吗？
Catching risk before it hits: can we effectively prevent first myocardial infarction?
捕捉边缘患者：如何早期识别动脉粥样硬化性心血管疾病？
Spotting patients at the edge: how do we identify atherosclerotic cardiovascular disease early?
专家小组：弥合差距——最优管理在何处失效？
Expert panel: closing the gap: where does optimal management break down?
Novartis
脂蛋白(a)：学习、重视、行动——明确风险、早检测、优管理
Lipoprotein(a): learn, prioritise, (a)ct – define risk, test early and optimise management
欢迎与介绍
Welcome and introduction
学习：理解脂蛋白(a) 在动脉粥样硬化性心血管疾病与冠脉血管体积评分中的作用
Learn: understanding the role of lipoprotein(a) in atherosclerotic cardiovascular disease and coronary artery volume score
优先关注：脂蛋白(a)检测与治疗优化的意义
Prioritise: the importance of lipoprotein(a) testing and treatment optimisation
「当下行动」：如今如何管理升高的脂蛋白(a)
(a)ct today: how elevated lipoprotein(a) is managed today
「前瞻明天」：研发中的靶向脂蛋白(a)疗法
(a)nticipate tomorrow: lipoprotein(a)-targeted therapies in development
问答
Q&A
… 另 1 项讲题
Abbott
床旁高敏肌钙蛋白对急诊流程的真实世界影响：英国大型三级中心早期结果
Real-world impact of point-of-care high-sensitivity troponin on emergency department flow: early results from a major United Kingdom tertiary centre
即时检验高敏肌钙蛋白对急诊科流程的真实世界影响：英国大型三级中心的早期结果
Real-world impact of point-of-care high-sensitivity troponin on emergency department flow: early results from a major United Kingdom tertiary centre
企业卫星会内容由赞助方支持，此处仅作学术日程信息陈列，不代表编辑立场。